APPLICATION NOTE
Matrigel dome assay and drug screening of colorectal cancer organoids
Get the most relevant data from valuable patient-derived organoids (PDOs)
With the onset of extensive 3D biology studies, we’ve come to a crossroads of transitioning from 2D biology-based research to more accurate and reliable 3D models. While there are several traditional in vitro assays for drug response studies, we need a better combination of 3D models, biology handling systems, and assays to come up with efficient ways to create and manage true representatives of in vivo complexity to address existing challenges in drug treatment strategies involving resistance.
In this application note, we feature the successful use of lab automation to assay patient-derived colorectal cancer organoids to improve workflows and develop an efficient method for compound testing applications.
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Product family
3D Biology
Product primary application
Bioassembly Bot 400; ImageXpress Confocal HT.ai; ImageXpress Micro Confocal High-Content Imaging System; MetaXpress High-Content Image Acquisition and Analysis Software
CMP
701Rn000005JkfPIAS
Title
Matrigel dome assay and drug screening of colorectal cancer organoids
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