APPLICATION NOTE
Neural outgrowth analysis in 3D human brain micro-tissues for compound screening applications
Brain micro-tissues reveal greater mechanistic insights as an industrial drug-screening platform
Brain micro-tissues show great promise in the study of neurological development and disease. However, they tend to be difficult to grow and can vary in shape, size, density, and opacity, thus rendering many unsuitable for high-throughput screening.
In this application note, we implemented high-content imaging of 3D brain micro-tissues to discover deeper insights and successfully develop an algorithm to analyze the neurites, nodes, and cell bodies. In addition, this innovative combination of high-content imaging with 3D human brain micro-tissues was applied to drug screening to reveal greater mechanistic insights as an industrial drug-screening platform.
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Imaging
Product primary application
DispenCell Single-Cell mageXpress Micro Confocal High-Content Imaging System; IN Carta Image Analysis Software; Bioassembly Bot 400
CMP
7014u000001AWoaAAG
Title
Neural outgrowth analysis in 3D human brain micro-tissues for compound screening applications
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